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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EEF2K All Species: 24.24
Human Site: Y59 Identified Species: 53.33
UniProt: O00418 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O00418 NP_037434.1 725 82144 Y59 V N S K V N K Y Y S N L T K S
Chimpanzee Pan troglodytes XP_001161085 725 82249 Y59 V N S K V N K Y Y S N L T K S
Rhesus Macaque Macaca mulatta XP_001092565 725 82310 Y59 V N S K V N K Y Y S N L T K S
Dog Lupus familis XP_536939 725 81954 Y59 V N S K V N N Y Y S N L T K S
Cat Felis silvestris
Mouse Mus musculus O08796 724 81720 Y59 V S S K V Q S Y Y S N L T K T
Rat Rattus norvegicus P70531 724 81471 Y59 V N S K G Q G Y Y N N L L K T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508333 641 73286 N41 C A T R H R Y N A V T G E W V
Chicken Gallus gallus XP_414920 725 82845 Y59 A S S K V D N Y Y S N L A K T
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001002740 706 80225 N70 G F C E F P K N L A H N Q Q L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans O01991 768 87807 P56 N D V V I E K P R M D P L H V
Sea Urchin Strong. purpuratus XP_788087 683 78401 N57 T H S T P I K N E N I N K T K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.9 97.5 93 N.A. 89.9 90 N.A. 75.3 78.7 N.A. 64.6 N.A. N.A. N.A. 38.6 45.5
Protein Similarity: 100 99.5 98.7 96.6 N.A. 94.7 94.3 N.A. 81.9 89.5 N.A. 75.4 N.A. N.A. N.A. 56.3 60.6
P-Site Identity: 100 100 100 93.3 N.A. 73.3 60 N.A. 0 60 N.A. 6.6 N.A. N.A. N.A. 6.6 13.3
P-Site Similarity: 100 100 100 93.3 N.A. 86.6 73.3 N.A. 13.3 80 N.A. 33.3 N.A. N.A. N.A. 26.6 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 10 0 0 0 0 0 0 10 10 0 0 10 0 0 % A
% Cys: 10 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 10 0 0 0 10 0 0 0 0 10 0 0 0 0 % D
% Glu: 0 0 0 10 0 10 0 0 10 0 0 0 10 0 0 % E
% Phe: 0 10 0 0 10 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 10 0 0 0 10 0 10 0 0 0 0 10 0 0 0 % G
% His: 0 10 0 0 10 0 0 0 0 0 10 0 0 10 0 % H
% Ile: 0 0 0 0 10 10 0 0 0 0 10 0 0 0 0 % I
% Lys: 0 0 0 64 0 0 55 0 0 0 0 0 10 64 10 % K
% Leu: 0 0 0 0 0 0 0 0 10 0 0 64 19 0 10 % L
% Met: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % M
% Asn: 10 46 0 0 0 37 19 28 0 19 64 19 0 0 0 % N
% Pro: 0 0 0 0 10 10 0 10 0 0 0 10 0 0 0 % P
% Gln: 0 0 0 0 0 19 0 0 0 0 0 0 10 10 0 % Q
% Arg: 0 0 0 10 0 10 0 0 10 0 0 0 0 0 0 % R
% Ser: 0 19 73 0 0 0 10 0 0 55 0 0 0 0 37 % S
% Thr: 10 0 10 10 0 0 0 0 0 0 10 0 46 10 28 % T
% Val: 55 0 10 10 55 0 0 0 0 10 0 0 0 0 19 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % W
% Tyr: 0 0 0 0 0 0 10 64 64 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _